Bedaquiline

CHEMBL376488 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

555.5 g/mol

LogP

7.2

Phase

4

A diarylquinolinyl antibiotic that specifically inhibits the ATP synthase of Mycobacterium tuberculosis, blocking the bacterium's energy production. It is a critical component of regimens for multidrug-resistant tuberculosis.

Masse moléculaire

555,5000 g/mol

LogP

7,20

TPSA

45,60 Å²

Règle des 5 de Lipinski

Non conforme

Aires thérapeutiques

Type 2 Diabetes HIV/AIDS Tuberculosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

COc1nc2ccc(Br)cc2cc1[C@@H](c1ccccc1)[C@@](O)(CCN(C)C)c1cccc2ccccc12

InChI

InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1

Molecular Formula

C32H31BrN2O2

HBD / HBA

1 / 4

Liaisons Rotatives

8

Atomes Lourds

37

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A diarylquinolinyl antibiotic that specifically inhibits the ATP synthase of Mycobacterium tuberculosis, blocking the bacterium's energy production. It is a critical component of regimens for multidrug-resistant tuberculosis.

Yes, Bedaquiline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL376488. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5388906. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C32H31BrN2O2
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.