Belumosudil

CHEMBL2005186 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

452.5 g/mol

LogP

4.8

Phase

4

A ROCK2 inhibitor that reduces the production of inflammatory cytokines and promotes regulatory T cell function to control chronic graft-versus-host disease. It is taken by mouth as a treatment for patients who have not responded to at least two prior therapies.

Masse moléculaire

452,5000 g/mol

LogP

4,80

TPSA

105,00 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Psoriasis Chronic Kidney Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CC(C)NC(=O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1

InChI

InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)

Molecular Formula

C26H24N6O2

HBD / HBA

3 / 6

Liaisons Rotatives

7

Atomes Lourds

34

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A ROCK2 inhibitor that reduces the production of inflammatory cytokines and promotes regulatory T cell function to control chronic graft-versus-host disease. It is taken by mouth as a treatment for patients who have not responded to at least two prior therapies.

Yes, Belumosudil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2005186. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 11950170. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C26H24N6O2
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.