Bromodiphenhydramine
A bromo-substituted analogue of diphenhydramine with antihistamine and sedative properties, historically used as a cough suppressant and for allergy symptoms. It works by blocking histamine H1 receptors and has anticholinergic effects. It is rarely used today and has been replaced by more selective antihistamines.
Masse moléculaire
334,2000 g/mol
LogP
4,00
TPSA
12,50 Ų
Règle des 5 de Lipinski
Conforme
Mécanisme d'action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Structure 2D
Cite this structure
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SMILES
CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1
InChI
InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3
Molecular Formula
C17H20BrNO
HBD / HBA
- / 2
Liaisons Rotatives
6
Atomes Lourds
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A bromo-substituted analogue of diphenhydramine with antihistamine and sedative properties, historically used as a cough suppressant and for allergy symptoms. It works by blocking histamine H1 receptors and has anticholinergic effects. It is rarely used today and has been replaced by more selective antihistamines.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Bromodiphenhydramine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201245. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2444. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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