Carbinoxamine
An antihistamine of the ethanolamine class that blocks H1 receptors to relieve allergy symptoms such as runny nose, sneezing, and itching. It also has sedative properties that can help with sleep disruption caused by allergies. It is used in adults and children for relief of upper respiratory allergy symptoms.
Masse moléculaire
290,7900 g/mol
LogP
2,90
TPSA
25,40 Ų
Règle des 5 de Lipinski
Conforme
Mécanisme d'action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Structure 2D
Cite this structure
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SMILES
CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1
InChI
InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
Molecular Formula
C16H19ClN2O
HBD / HBA
- / 3
Liaisons Rotatives
6
Atomes Lourds
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
An antihistamine of the ethanolamine class that blocks H1 receptors to relieve allergy symptoms such as runny nose, sneezing, and itching. It also has sedative properties that can help with sleep disruption caused by allergies. It is used in adults and children for relief of upper respiratory allergy symptoms.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Carbinoxamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL864. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2564. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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