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Ceftriaxone

CHEMBL161 Phase 4 Approuvé Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
554.6 g/mol
LogP
-1.3
Phase
4

A widely used third-generation cephalosporin antibiotic with broad-spectrum activity and a long half-life allowing once-daily dosing, used for a range of serious infections including meningitis, community-acquired pneumonia, gonorrhea, and Lyme disease. It is available only for parenteral use and is eliminated via both renal and biliary routes, making it useful when renal function is compromised. It should not be mixed with calcium-containing IV solutions due to the risk of precipitate formation.

Masse moléculaire

554,6000 g/mol

LogP

-1,30

TPSA

288,00 Ų

Règle des 5 de Lipinski

Non conforme

Aires thérapeutiques

Benign Prostatic Hyperplasia Cardiovascular Disease Chronic Obstructive Pulmonary Disease Parkinson's Disease Schizophrenia Bipolar Disorder Infectious Disease Gastroesophageal Reflux Disease Inflammatory Bowel Disease Stroke Hypertension HIV/AIDS Tuberculosis

Mécanisme d'action

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mécanisme

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

Structure 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H18N8O7S3

                    

                    
                    

                        
HBD / HBA

                        
4 / 13

                    

                    
                    

                        
Liaisons Rotatives

                        
8

                    

                    
                    
                    

                        
Atomes Lourds

                        
36

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Foire aux questions

                

                    
                    

                        
                        

                            
A widely used third-generation cephalosporin antibiotic with broad-spectrum activity and a long half-life allowing once-daily dosing, used for a range of serious infections including meningitis, community-acquired pneumonia, gonorrhea, and Lyme disease. It is available only for parenteral use and is eliminated via both renal and biliary routes, making it useful when renal function is compromised. It should not be mixed with calcium-containing IV solutions due to the risk of precipitate formation.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Ceftriaxone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL161.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5479530.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Avertissement médical

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.