Cerivastatin Sodium
The sodium salt form of cerivastatin was the clinical formulation of this withdrawn statin. Sharing the same mechanism and safety profile as the parent compound, it was removed from the market due to fatal cases of muscle breakdown. It is no longer available for clinical use.
Masse moléculaire
481,5000 g/mol
TPSA
103,00 Ų
Aires thérapeutiques
Mécanisme d'action
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Structure 2D
Cite this structure
Embed this structure
SMILES
COCc1c(C(C)C)nc(C(C)C)c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])c1-c1ccc(F)cc1.[Na+]
InChI
InChI=1S/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1
Molecular Formula
C26H33FNNaO5
HBD / HBA
2 / 7
Liaisons Rotatives
11
Atomes Lourds
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
The sodium salt form of cerivastatin was the clinical formulation of this withdrawn statin. Sharing the same mechanism and safety profile as the parent compound, it was removed from the market due to fatal cases of muscle breakdown. It is no longer available for clinical use.
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Yes, Cerivastatin Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200563. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 23663992. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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