Chlophedianol
A centrally acting antitussive agent that suppresses the cough reflex to provide symptomatic relief from nonproductive cough. It is often used in combination with other cough and cold ingredients. It has mild antihistamine and anticholinergic properties in addition to its cough-suppressing activity.
Masse moléculaire
289,8000 g/mol
LogP
3,60
TPSA
23,50 Ų
Règle des 5 de Lipinski
Conforme
Mécanisme d'action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Structure 2D
Cite this structure
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SMILES
CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl
InChI
InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3
Molecular Formula
C17H20ClNO
HBD / HBA
1 / 2
Liaisons Rotatives
5
Atomes Lourds
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A centrally acting antitussive agent that suppresses the cough reflex to provide symptomatic relief from nonproductive cough. It is often used in combination with other cough and cold ingredients. It has mild antihistamine and anticholinergic properties in addition to its cough-suppressing activity.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Chlophedianol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201313. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2795. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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