Chlophedianol

CHEMBL1201313 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

289.8 g/mol

LogP

3.6

Phase

4

Cough suppression by central action defines chlophedianol, which damps the cough reflex to relieve nonproductive cough rather than altering secretions in the airway. Mild antihistaminic and anticholinergic properties accompany that primary activity, and they account for part of the agent's side-effect profile. Formulations commonly combine it with other cough and cold ingredients rather than presenting it alone. The compound is a small molecule with the formula C17H20ClNO and a molecular weight of approximately 289.8 g/mol, and it is an approved agent whose clinical development reached the final phase. Its symptomatic role should be distinguished from that of expectorants and mucolytics, which target sputum rather than the reflex arc itself.

A centrally acting antitussive agent that suppresses the cough reflex to provide symptomatic relief from nonproductive cough. It is often used in combination with other cough and cold ingredients. It has mild antihistamine and anticholinergic properties in addition to its cough-suppressing activity.

Masse moléculaire

289,8000 g/mol

LogP

3,60

TPSA

23,50 Å²

Règle des 5 de Lipinski

Conforme

Mécanisme d'action

A centrally acting non-opioid antitussive. Chlophedianol raises the threshold of the medullary cough centre, suppressing the cough reflex without acting at opioid receptors. It also carries mild local anaesthetic and anticholinergic activity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mécanisme

A centrally acting non-opioid antitussive. Chlophedianol raises the threshold of the medullary cough centre, suppressing the cough reflex without acting at opioid receptors. It also carries mild local anaesthetic and …

Structure 2D

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SMILES

CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl

InChI

InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3

Molecular Formula

C17H20ClNO

HBD / HBA

1 / 2

Liaisons Rotatives

5

Atomes Lourds

20

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A centrally acting antitussive agent that suppresses the cough reflex to provide symptomatic relief from nonproductive cough. It is often used in combination with other cough and cold ingredients. It has mild antihistamine and anticholinergic properties in addition to its cough-suppressing activity.

A centrally acting non-opioid antitussive. Chlophedianol raises the threshold of the medullary cough centre, suppressing the cough reflex without acting at opioid receptors. It also carries mild local anaesthetic and anticholinergic activity.

Yes, Chlophedianol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201313. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 2795. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.

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Structure

Données Clés

Formule: C17H20ClNO
Synonymes: 15

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.