Chlorpheniramine Maleate
The maleate salt form of chlorpheniramine is the most commonly used preparation of this first-generation antihistamine, found in numerous oral cold and allergy medications. It relieves sneezing, runny nose, and itching but causes sedation in many patients. Caution is needed in elderly patients due to anticholinergic side effects including urinary retention and confusion.
Masse moléculaire
390,9000 g/mol
TPSA
90,70 Ų
Aires thérapeutiques
Mécanisme d'action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Structure 2D
Cite this structure
Embed this structure
SMILES
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
InChI
InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Molecular Formula
C20H23ClN2O4
HBD / HBA
2 / 6
Liaisons Rotatives
7
Atomes Lourds
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
The maleate salt form of chlorpheniramine is the most commonly used preparation of this first-generation antihistamine, found in numerous oral cold and allergy medications. It relieves sneezing, runny nose, and itching but causes sedation in many patients. Caution is needed in elderly patients due to anticholinergic side effects including urinary retention and confusion.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Chlorpheniramine Maleate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1659. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5281068. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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