Ciclopirox
A broad-spectrum antifungal and antibacterial agent that works by chelating metal cations necessary for fungal enzyme function, disrupting cell membrane integrity and metabolic processes. It is used topically to treat fungal nail infections (onychomycosis), tinea pedis, tinea versicolor, and seborrheic dermatitis. Multiple formulations are available including nail lacquer, cream, and shampoo.
Masse moléculaire
207,2700 g/mol
LogP
2,00
TPSA
40,50 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Structure 2D
Cite this structure
Embed this structure
SMILES
Cc1cc(C2CCCCC2)n(O)c(=O)c1
InChI
InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3
Molecular Formula
C12H17NO2
HBD / HBA
1 / 2
Liaisons Rotatives
1
Atomes Lourds
15
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A broad-spectrum antifungal and antibacterial agent that works by chelating metal cations necessary for fungal enzyme function, disrupting cell membrane integrity and metabolic processes. It is used topically to treat fungal nail infections (onychomycosis), tinea pedis, tinea versicolor, and seborrheic dermatitis. Multiple formulations are available including nail lacquer, cream, and shampoo.
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Yes, Ciclopirox is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1413. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2749. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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