Clemastine
An antihistamine that blocks H1 receptors to relieve allergy symptoms such as itching, hives, and runny nose. It is taken by mouth and may cause drowsiness due to its ability to cross into the brain.
Masse moléculaire
343,9000 g/mol
LogP
5,00
TPSA
12,50 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Structure 2D
Cite this structure
Embed this structure
SMILES
CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1
InChI
InChI=1S/C21H26ClNO/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3/t20-,21-/m1/s1
Molecular Formula
C21H26ClNO
HBD / HBA
- / 2
Liaisons Rotatives
6
Atomes Lourds
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
An antihistamine that blocks H1 receptors to relieve allergy symptoms such as itching, hives, and runny nose. It is taken by mouth and may cause drowsiness due to its ability to cross into the brain.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Clemastine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1626. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 26987. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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