Cyclophosphamide
A nitrogen mustard alkylating agent that cross-links DNA strands to kill rapidly dividing cells, used to treat various cancers including lymphoma, leukemia, and breast cancer, as well as severe autoimmune diseases. It requires activation by liver enzymes and can cause serious side effects including hemorrhagic cystitis.
Masse moléculaire
261,0800 g/mol
LogP
0,60
TPSA
41,60 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
Structure 2D
Cite this structure
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SMILES
O.O=P1(N(CCCl)CCCl)NCCCO1
InChI
InChI=1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
Molecular Formula
C7H15Cl2N2O2P
HBD / HBA
1 / 4
Liaisons Rotatives
5
Atomes Lourds
14
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A nitrogen mustard alkylating agent that cross-links DNA strands to kill rapidly dividing cells, used to treat various cancers including lymphoma, leukemia, and breast cancer, as well as severe autoimmune diseases. It requires activation by liver enzymes and can cause serious side effects including hemorrhagic cystitis.
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
Yes, Cyclophosphamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200796. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2907. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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