Darifenacin
A selective muscarinic M3 receptor antagonist used to treat overactive bladder by reducing involuntary bladder contractions that cause urgency, frequency, and urge incontinence. Its relative M3 selectivity may reduce some anticholinergic side effects compared to less selective agents.
Masse moléculaire
426,5000 g/mol
LogP
4,60
TPSA
55,60 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Structure 2D
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SMILES
NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(CCc2ccc3c(c2)CCO3)C1
InChI
InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1
Molecular Formula
C28H30N2O2
HBD / HBA
1 / 3
Liaisons Rotatives
7
Atomes Lourds
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A selective muscarinic M3 receptor antagonist used to treat overactive bladder by reducing involuntary bladder contractions that cause urgency, frequency, and urge incontinence. Its relative M3 selectivity may reduce some anticholinergic side effects compared to less selective agents.
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Yes, Darifenacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1346. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 444031. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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