Darolutamide

CHEMBL4297185 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

398.8 g/mol

LogP

1.8

Phase

4

A nonsteroidal antiandrogen used to treat non-metastatic castration-resistant prostate cancer by blocking androgen receptors that drive cancer cell growth. It penetrates the blood-brain barrier poorly compared to some other antiandrogens, which may result in fewer neurological side effects. It is taken as oral tablets twice daily with food.

Masse moléculaire

398,8000 g/mol

LogP

1,80

TPSA

120,00 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CC(O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)n[nH]1

InChI

InChI=1S/C19H19ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11-12,27H,10H2,1-2H3,(H,22,28)(H,23,24)/t11-,12?/m0/s1

Molecular Formula

C19H19ClN6O2

HBD / HBA

3 / 5

Liaisons Rotatives

6

Atomes Lourds

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A nonsteroidal antiandrogen used to treat non-metastatic castration-resistant prostate cancer by blocking androgen receptors that drive cancer cell growth. It penetrates the blood-brain barrier poorly compared to some other antiandrogens, which may result in fewer neurological side effects. It is taken as oral tablets twice daily with food.

Yes, Darolutamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297185. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 67171867. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C19H19ClN6O2
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.