Demecarium
A long-acting irreversible cholinesterase inhibitor eye drop used for chronic open-angle glaucoma and accommodative esotropia in children. Its use has largely been replaced by more modern glaucoma therapies due to its side effect profile.
Masse moléculaire
556,8000 g/mol
LogP
6,60
TPSA
59,10 Ų
Règle des 5 de Lipinski
Non conforme
Mécanisme d'action
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
Structure 2D
Cite this structure
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SMILES
CN(CCCCCCCCCCN(C)C(=O)Oc1cccc([N+](C)(C)C)c1)C(=O)Oc1cccc([N+](C)(C)C)c1
InChI
InChI=1S/C32H52N4O4/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8/h17-22,25-26H,9-16,23-24H2,1-8H3/q+2
Molecular Formula
C32H52N4O4+2
HBD / HBA
- / 4
Liaisons Rotatives
17
Atomes Lourds
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A long-acting irreversible cholinesterase inhibitor eye drop used for chronic open-angle glaucoma and accommodative esotropia in children. Its use has largely been replaced by more modern glaucoma therapies due to its side effect profile.
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
Yes, Demecarium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201229. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5966. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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