Dexchlorpheniramine
The pharmacologically active dextrorotatory isomer of chlorpheniramine, an antihistamine used to relieve symptoms of allergic rhinitis and urticaria. It has greater antihistamine potency than the racemate.
Masse moléculaire
274,7900 g/mol
LogP
3,40
TPSA
16,10 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Structure 2D
Cite this structure
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SMILES
CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1
InChI
InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
Molecular Formula
C16H19ClN2
HBD / HBA
- / 2
Liaisons Rotatives
5
Atomes Lourds
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
The pharmacologically active dextrorotatory isomer of chlorpheniramine, an antihistamine used to relieve symptoms of allergic rhinitis and urticaria. It has greater antihistamine potency than the racemate.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Dexchlorpheniramine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201353. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 33036. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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