Dolutegravir
An integrase strand transfer inhibitor used as part of combination antiretroviral therapy for HIV infection, working by blocking the viral integrase enzyme that incorporates HIV's genetic material into human cell DNA. It is highly effective, has a high barrier to resistance, and is recommended as a preferred component of first-line HIV treatment. It is also available in combination pills to reduce the number of tablets patients need to take daily.
Masse moléculaire
419,4000 g/mol
LogP
2,40
TPSA
99,20 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.
Structure 2D
Cite this structure
Embed this structure
SMILES
C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
InChI
InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1
Molecular Formula
C20H19F2N3O5
HBD / HBA
2 / 8
Liaisons Rotatives
3
Atomes Lourds
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
An integrase strand transfer inhibitor used as part of combination antiretroviral therapy for HIV infection, working by blocking the viral integrase enzyme that incorporates HIV's genetic material into human cell DNA. It is highly effective, has a high barrier to resistance, and is recommended as a preferred component of first-line HIV treatment. It is also available in combination pills to reduce the number of tablets patients need to take daily.
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.
Yes, Dolutegravir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1229211. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54726191. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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