Dorzolamide
A carbonic anhydrase inhibitor used as an eye drop to lower intraocular pressure in patients with glaucoma or ocular hypertension. It reduces fluid production inside the eye to help protect against vision loss.
Masse moléculaire
324,4000 g/mol
LogP
0,40
TPSA
151,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Structure 2D
Cite this structure
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SMILES
CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(S(N)(=O)=O)cc21
InChI
InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
Molecular Formula
C10H16N2O4S3
HBD / HBA
2 / 7
Liaisons Rotatives
3
Atomes Lourds
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A carbonic anhydrase inhibitor used as an eye drop to lower intraocular pressure in patients with glaucoma or ocular hypertension. It reduces fluid production inside the eye to help protect against vision loss.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Dorzolamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL218490. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5284549. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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