Doxacurium
A neuromuscular blocking agent used during surgery and mechanical ventilation to cause temporary muscle paralysis. It works by blocking the transmission of nerve signals to muscles.
Masse moléculaire
1035,2000 g/mol
LogP
7,40
TPSA
163,00 Ų
Règle des 5 de Lipinski
Non conforme
Mécanisme d'action
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Structure 2D
Cite this structure
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SMILES
COc1cc(CC2c3c(cc(OC)c(OC)c3OC)CC[N+]2(C)CCCOC(=O)CCC(=O)OCCC[N+]2(C)CCc3cc(OC)c(OC)c(OC)c3C2Cc2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC
InChI
InChI=1S/C56H78N2O16/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6/h29-34,39-40H,15-28H2,1-14H3/q+2
Molecular Formula
C56H78N2O16+2
HBD / HBA
- / 16
Liaisons Rotatives
29
Atomes Lourds
74
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A neuromuscular blocking agent used during surgery and mechanical ventilation to cause temporary muscle paralysis. It works by blocking the transmission of nerve signals to muscles.
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Yes, Doxacurium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1237123. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60169. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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