Fedratinib

CHEMBL1287853 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

524.7 g/mol

LogP

4.8

Phase

4

This oral medication blocks JAK2, an enzyme that is overactivated in certain blood cancers, slowing the abnormal growth of blood cells. It is used to treat myelofibrosis and polycythemia vera.

Masse moléculaire

524,7000 g/mol

LogP

4,80

TPSA

117,00 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1

InChI

InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

Molecular Formula

C27H36N6O3S

HBD / HBA

3 / 9

Liaisons Rotatives

11

Atomes Lourds

37

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

This oral medication blocks JAK2, an enzyme that is overactivated in certain blood cancers, slowing the abnormal growth of blood cells. It is used to treat myelofibrosis and polycythemia vera.

Yes, Fedratinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1287853. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 16722836. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C27H36N6O3S
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.