Felodipine
This calcium channel blocker relaxes the walls of blood vessels by preventing calcium from entering smooth muscle cells, lowering blood pressure and improving blood flow. It is used to treat hypertension and angina.
Masse moléculaire
384,2000 g/mol
LogP
3,90
TPSA
64,60 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Blocks L-type voltage-gated calcium channels in vascular smooth muscle and cardiac myocytes, reducing calcium influx during depolarization. This produces vasodilation, decreased myocardial contractility, and reduced heart rate.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks L-type voltage-gated calcium channels in vascular smooth muscle and cardiac myocytes, reducing calcium influx during depolarization. This produces vasodilation, decreased myocardial contractility, and reduced heart rate.
Structure 2D
Cite this structure
Embed this structure
SMILES
CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl
InChI
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
Molecular Formula
C18H19Cl2NO4
HBD / HBA
1 / 5
Liaisons Rotatives
6
Atomes Lourds
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This calcium channel blocker relaxes the walls of blood vessels by preventing calcium from entering smooth muscle cells, lowering blood pressure and improving blood flow. It is used to treat hypertension and angina.
Blocks L-type voltage-gated calcium channels in vascular smooth muscle and cardiac myocytes, reducing calcium influx during depolarization. This produces vasodilation, decreased myocardial contractility, and reduced heart rate.
Yes, Felodipine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1480. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3333. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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