Fezolinetant

CHEMBL3608680 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

358.4 g/mol

LogP

1.6

Phase

4

A non-hormonal medication that works by blocking neurokinin 3 receptors in the brain to reduce the frequency and severity of hot flashes in postmenopausal women. It provides relief without the use of estrogen, making it an option for those who cannot or prefer not to use hormone therapy.

Masse moléculaire

358,4000 g/mol

LogP

1,60

TPSA

105,00 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Cardiovascular Disease Breast Cancer Prostate Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1

InChI

InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1

Molecular Formula

C16H15FN6OS

HBD / HBA

- / 7

Liaisons Rotatives

2

Atomes Lourds

25

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A non-hormonal medication that works by blocking neurokinin 3 receptors in the brain to reduce the frequency and severity of hot flashes in postmenopausal women. It provides relief without the use of estrogen, making it an option for those who cannot or prefer not to use hormone therapy.

Yes, Fezolinetant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3608680. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 117604931. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C16H15FN6OS
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.