Finafloxacin
A fluoroquinolone antibiotic used to treat acute otitis externa (swimmer's ear) caused by susceptible bacteria. It is applied directly to the ear canal to fight infection, including strains that are resistant to other antibiotics.
Masse moléculaire
398,4000 g/mol
LogP
-0,70
TPSA
106,00 Ų
Règle des 5 de Lipinski
Conforme
Mécanisme d'action
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Structure 2D
Cite this structure
Embed this structure
SMILES
N#Cc1c(N2C[C@@H]3NCCO[C@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12
InChI
InChI=1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1
Molecular Formula
C20H19FN4O4
HBD / HBA
2 / 9
Liaisons Rotatives
3
Atomes Lourds
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A fluoroquinolone antibiotic used to treat acute otitis externa (swimmer's ear) caused by susceptible bacteria. It is applied directly to the ear canal to fight infection, including strains that are resistant to other antibiotics.
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Yes, Finafloxacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1908370. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11567473. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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