Fosamprenavir Calcium
This calcium salt prodrug form is converted by enzymes in the intestinal wall to amprenavir, which then inhibits the HIV protease enzyme to prevent viral replication. It is used in combination with other antiretrovirals to treat HIV/AIDS and offers improved absorption compared to the parent drug.
Masse moléculaire
623,7000 g/mol
TPSA
192,00 Ų
Aires thérapeutiques
Mécanisme d'action
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Structure 2D
Cite this structure
Embed this structure
SMILES
CC(C)CN(C[C@@H](OP(=O)([O-])[O-])[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1.[Ca+2]
InChI
InChI=1S/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);/q;+2/p-2/t21-,23-,24+;/m0./s1
Molecular Formula
C25H34CaN3O9PS
HBD / HBA
2 / 11
Liaisons Rotatives
13
Atomes Lourds
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This calcium salt prodrug form is converted by enzymes in the intestinal wall to amprenavir, which then inhibits the HIV protease enzyme to prevent viral replication. It is used in combination with other antiretrovirals to treat HIV/AIDS and offers improved absorption compared to the parent drug.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Fosamprenavir Calcium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200734. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 131535. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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