Fosinopril Sodium
This sodium salt form of fosinopril is an ACE inhibitor used to lower high blood pressure and treat heart failure by reducing the production of angiotensin II, which narrows blood vessels. Unlike many other ACE inhibitors, it is eliminated through both the liver and kidneys, making dosing adjustments less critical in kidney impairment.
Masse moléculaire
585,6000 g/mol
TPSA
113,00 Ų
Aires thérapeutiques
Mécanisme d'action
Inhibits angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This reduces peripheral vascular resistance, decreases aldosterone secretion, and lowers blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This reduces peripheral vascular resistance, decreases aldosterone secretion, and lowers blood pressure.
Structure 2D
Cite this structure
Embed this structure
SMILES
CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)[O-])C(C)C.[Na+]
InChI
InChI=1S/C30H46NO7P.Na/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24;/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35);/q;+1/p-1/t25-,26+,30+,39-;/m1./s1
Molecular Formula
C30H45NNaO7P
HBD / HBA
- / 7
Liaisons Rotatives
15
Atomes Lourds
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This sodium salt form of fosinopril is an ACE inhibitor used to lower high blood pressure and treat heart failure by reducing the production of angiotensin II, which narrows blood vessels. Unlike many other ACE inhibitors, it is eliminated through both the liver and kidneys, making dosing adjustments less critical in kidney impairment.
Inhibits angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This reduces peripheral vascular resistance, decreases aldosterone secretion, and lowers blood pressure.
Yes, Fosinopril Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3039596. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 23681451. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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