Glasdegib Maleate

CHEMBL4297534 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

490.5 g/mol

LogP

—

Phase

4

A maleate salt form of glasdegib, a Smoothened inhibitor used in combination chemotherapy regimens for acute myeloid leukemia in patients unfit for intensive treatment. The maleate salt is the commercially approved formulation that ensures adequate oral bioavailability. It works by disrupting the hedgehog signaling that sustains leukemia cell populations.

Masse moléculaire

490,5000 g/mol

TPSA

171,00 Å²

Aires thérapeutiques

Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CN1CC[C@@H](NC(=O)Nc2ccc(C#N)cc2)C[C@@H]1c1nc2ccccc2[nH]1.O=C(O)/C=C\C(=O)O

InChI

InChI=1S/C21H22N6O.C4H4O4/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20;5-3(6)1-2-4(7)8/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28);1-2H,(H,5,6)(H,7,8)/b;2-1-/t16-,19-;/m1./s1

Molecular Formula

C25H26N6O5

HBD / HBA

5 / 8

Liaisons Rotatives

5

Atomes Lourds

36

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A maleate salt form of glasdegib, a Smoothened inhibitor used in combination chemotherapy regimens for acute myeloid leukemia in patients unfit for intensive treatment. The maleate salt is the commercially approved formulation that ensures adequate oral bioavailability. It works by disrupting the hedgehog signaling that sustains leukemia cell populations.

Yes, Glasdegib Maleate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297534. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 122640033. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C25H26N6O5

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.