Guanethidine

CHEMBL765 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

198.3 g/mol

LogP

0.5

Phase

4

An antihypertensive medication that works by preventing the release of norepinephrine from peripheral sympathetic nerves, significantly reducing blood pressure in patients with moderate to severe hypertension. It was widely used before more modern antihypertensives became available but fell out of favor due to significant orthostatic hypotension and other side effects. It still sees occasional use in specialized clinical situations such as ophthalmic drops for glaucoma.

Masse moléculaire

198,3100 g/mol

LogP

0,50

TPSA

67,60 Å²

Règle des 5 de Lipinski

Conforme

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

N=C(N)NCCN1CCCCCCC1

InChI

InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)

Molecular Formula

C10H22N4

HBD / HBA

2 / 2

Liaisons Rotatives

3

Atomes Lourds

14

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

An antihypertensive medication that works by preventing the release of norepinephrine from peripheral sympathetic nerves, significantly reducing blood pressure in patients with moderate to severe hypertension. It was widely used before more modern antihypertensives became available but fell out of favor due to significant orthostatic hypotension and other side effects. It still sees occasional use in specialized clinical situations such as ophthalmic drops for glaucoma.

Yes, Guanethidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL765. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3518. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C10H22N4

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.