Hydrocortisone Butyrate
A butyrate ester of hydrocortisone with greater lipophilicity than the parent compound, used as a moderate-potency topical corticosteroid for inflammatory skin conditions such as atopic dermatitis and psoriasis. This formulation penetrates the skin effectively to deliver anti-inflammatory activity with relatively lower systemic absorption. It is available in cream and ointment formulations for external use.
Masse moléculaire
432,5000 g/mol
LogP
3,20
TPSA
101,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Structure 2D
Cite this structure
Embed this structure
SMILES
CCCC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C
InChI
InChI=1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1
Molecular Formula
C25H36O6
HBD / HBA
2 / 6
Liaisons Rotatives
6
Atomes Lourds
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A butyrate ester of hydrocortisone with greater lipophilicity than the parent compound, used as a moderate-potency topical corticosteroid for inflammatory skin conditions such as atopic dermatitis and psoriasis. This formulation penetrates the skin effectively to deliver anti-inflammatory activity with relatively lower systemic absorption. It is available in cream and ointment formulations for external use.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Hydrocortisone Butyrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1683. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 26133. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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