Ixabepilone
This epothilone analogue chemotherapy drug works by stabilizing microtubules in cancer cells, preventing their disassembly and blocking cell division, similar to taxanes but effective in some taxane-resistant tumors. It is used to treat advanced or metastatic breast cancer, particularly in patients whose disease has progressed after prior anthracycline and taxane therapies. Peripheral neuropathy is a common side effect.
Masse moléculaire
506,7000 g/mol
LogP
3,60
TPSA
140,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Structure 2D
Cite this structure
Embed this structure
SMILES
C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)N1
InChI
InChI=1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
Molecular Formula
C27H42N2O5S
HBD / HBA
3 / 7
Liaisons Rotatives
2
Atomes Lourds
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This epothilone analogue chemotherapy drug works by stabilizing microtubules in cancer cells, preventing their disassembly and blocking cell division, similar to taxanes but effective in some taxane-resistant tumors. It is used to treat advanced or metastatic breast cancer, particularly in patients whose disease has progressed after prior anthracycline and taxane therapies. Peripheral neuropathy is a common side effect.
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Yes, Ixabepilone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201752. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6445540. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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