Ketoconazole
An antifungal medication that also blocks androgen synthesis, making it useful for treating fungal infections as well as hormone-sensitive cancers such as prostate and breast cancer. It inhibits the CYP17A1 enzyme involved in steroid hormone production.
Masse moléculaire
531,4000 g/mol
LogP
4,30
TPSA
69,10 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Structure 2D
Cite this structure
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SMILES
CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1
InChI
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3
Molecular Formula
C26H28Cl2N4O4
HBD / HBA
- / 6
Liaisons Rotatives
7
Atomes Lourds
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
An antifungal medication that also blocks androgen synthesis, making it useful for treating fungal infections as well as hormone-sensitive cancers such as prostate and breast cancer. It inhibits the CYP17A1 enzyme involved in steroid hormone production.
Yes, Ketoconazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL157101. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 47576. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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