Larotrectinib Sulfate

CHEMBL3989939 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

526.5 g/mol

LogP

—

Phase

4

The sulfate salt form of larotrectinib, a TRK kinase inhibitor used to treat cancers with NTRK gene fusions including colorectal and breast cancers. It shares the same tumor-agnostic mechanism as the parent compound.

Masse moléculaire

526,5000 g/mol

TPSA

169,00 Å²

Aires thérapeutiques

Melanoma Lymphoma Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1.O=S(=O)(O)O

InChI

InChI=1S/C21H22F2N6O2.H2O4S/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27;1-5(2,3)4/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31);(H2,1,2,3,4)/t14-,18+;/m0./s1

Molecular Formula

C21H24F2N6O6S

HBD / HBA

4 / 11

Liaisons Rotatives

3

Atomes Lourds

36

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

The sulfate salt form of larotrectinib, a TRK kinase inhibitor used to treat cancers with NTRK gene fusions including colorectal and breast cancers. It shares the same tumor-agnostic mechanism as the parent compound.

Yes, Larotrectinib Sulfate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989939. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 67330085. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C21H24F2N6O6S

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.