Letermovir

CHEMBL1241951 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

572.5 g/mol

LogP

4.6

Phase

4

This antiviral inhibits CMV terminase complex by a unique mechanism, preventing cytomegalovirus infection after stem cell transplant.

Masse moléculaire

572,5000 g/mol

LogP

4,60

TPSA

77,80 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Lymphoma HIV/AIDS Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1

InChI

InChI=1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1

Molecular Formula

C29H28F4N4O4

HBD / HBA

1 / 10

Liaisons Rotatives

7

Atomes Lourds

41

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

This antiviral inhibits CMV terminase complex by a unique mechanism, preventing cytomegalovirus infection after stem cell transplant.

Yes, Letermovir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1241951. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 45138674. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C29H28F4N4O4
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.