Losartan
Losartan lowers blood pressure by selectively blocking the AT1 receptor, the site through which angiotensin II constricts blood vessels. Preventing that hormone from binding allows vessels to relax, and as an angiotensin II receptor blocker it achieves this without the bradykinin-related cough associated with ACE inhibitors. It is used for high blood pressure, the kidney disease of diabetes, and heart failure. A small molecule (C22H23ClN6O) with a parent half-life of about 2 hours, its effect is carried further by an active metabolite that sustains receptor blockade through the day. By acting at the receptor rather than on the enzyme that makes angiotensin II, it blocks the hormone's effect at the final step of the pathway. Losartan is an approved cardiovascular medicine widely used for blood-pressure and kidney protection.
An angiotensin II receptor blocker (ARB) used to treat high blood pressure, diabetic kidney disease, and heart failure, and studied for potential benefits in Alzheimer's disease and atrial fibrillation. It selectively blocks the AT1 receptor to relax blood vessels.
Masse moléculaire
422,9200 g/mol
LogP
4,30
TPSA
92,50 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Classes de médicaments
Mécanisme d'action
Angiotensin II receptor type 1 antagonist.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Angiotensin II receptor type 1 antagonist.
Structure 2D
Cite this structure
Embed this structure
SMILES
CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
InChI
InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
Molecular Formula
C22H23ClN6O
HBD / HBA
2 / 5
Liaisons Rotatives
8
Atomes Lourds
30
ARBs combined with spironolactone substantially increase hyperkalemia risk through additive suppression of renal potassium excretion.
Trimethoprim blocks renal tubular secretion of potassium, acting like a potassium-sparing diuretic; combined with losartan's reduction of aldosterone-mediated potassium excretion, the risk of hyperkalaemia is substantially increased.
Dual RAAS blockade with ACE inhibitors and ARBs provides no additional cardiovascular benefit over either agent alone and significantly increases the risk of hypotension, hyperkalemia, and acute kidney injury.
Losartan + hydrochlorothiazide is a guideline-recommended combination for hypertension; the primary interactions are additive hypotension and variable electrolyte effects.
Empagliflozin and losartan can both reduce blood pressure and lower serum potassium/sodium; combined use may increase the risk of dehydration, hypotension, and electrolyte imbalance.
Ibuprofen attenuates the antihypertensive effect of ARBs and increases the risk of renal impairment and hyperkalemia.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
An angiotensin II receptor blocker (ARB) used to treat high blood pressure, diabetic kidney disease, and heart failure, and studied for potential benefits in Alzheimer's disease and atrial fibrillation. It selectively blocks the AT1 receptor to relax blood vessels.
Angiotensin II receptor type 1 antagonist.
Key pharmacokinetic parameters for Losartan: Half-life: 2 hours.
Yes, Losartan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL191. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3961. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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