Lusutrombopag
A small-molecule thrombopoietin receptor agonist used to treat low platelet counts in adults with chronic liver disease preparing for a scheduled procedure. It stimulates the bone marrow to produce more platelets.
Masse moléculaire
591,5000 g/mol
LogP
7,70
TPSA
126,00 Ų
Règle des 5 de Lipinski
Non conforme
Aires thérapeutiques
Mécanisme d'action
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Structure 2D
Cite this structure
Embed this structure
SMILES
CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC
InChI
InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1
Molecular Formula
C29H32Cl2N2O5S
HBD / HBA
2 / 7
Liaisons Rotatives
13
Atomes Lourds
39
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A small-molecule thrombopoietin receptor agonist used to treat low platelet counts in adults with chronic liver disease preparing for a scheduled procedure. It stimulates the bone marrow to produce more platelets.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Lusutrombopag is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2107831. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 49843517. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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