Maralixibat

CHEMBL363392 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

675.0 g/mol

LogP

7.1

Phase

4

An ileal bile acid transporter (IBAT) inhibitor used to treat cholestatic pruritus (severe itching) in children with progressive familial intrahepatic cholestasis (PFIC) by reducing the reabsorption of bile acids from the intestine. This helps lower bile acid levels in the blood and alleviate itching.

Masse moléculaire

675,0000 g/mol

LogP

7,10

TPSA

78,50 Å²

Règle des 5 de Lipinski

Non conforme

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2ccc(OCc3ccc(C[N+]45CCN(CC4)CC5)cc3)cc2)[C@H]1O

InChI

InChI=1S/C40H56N3O4S/c1-5-7-19-40(20-8-6-2)30-48(45,46)37-18-15-34(41(3)4)27-36(37)38(39(40)44)33-13-16-35(17-14-33)47-29-32-11-9-31(10-12-32)28-43-24-21-42(22-25-43)23-26-43/h9-18,27,38-39,44H,5-8,19-26,28-30H2,1-4H3/q+1/t38-,39-/m1/s1

Molecular Formula

C40H56N3O4S+

HBD / HBA

1 / 6

Liaisons Rotatives

13

Atomes Lourds

48

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

An ileal bile acid transporter (IBAT) inhibitor used to treat cholestatic pruritus (severe itching) in children with progressive familial intrahepatic cholestasis (PFIC) by reducing the reabsorption of bile acids from the intestine. This helps lower bile acid levels in the blood and alleviate itching.

Yes, Maralixibat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL363392. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 9831643. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C40H56N3O4S+
Synonymes: 1

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.