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Methotrexate Sodium

CHEMBL3244648 Phase 4 Approuvé Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
498.4 g/mol
LogP
—
Phase
4

A sodium salt form of methotrexate, used both as a chemotherapy agent for cancers and at low doses for autoimmune diseases such as rheumatoid arthritis and psoriasis.

Masse moléculaire

498,4000 g/mol

TPSA

216,00 Ų

Aires thérapeutiques

Bladder Cancer Rheumatoid Arthritis Psoriasis Lymphoma Breast Cancer Leukemia

Mécanisme d'action

Dihydrofolate reductase inhibitor.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mécanisme

Dihydrofolate reductase inhibitor.

Structure 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1.[Na+].[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C20H22N8O5.2Na/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);;/q;2*+1/p-2/t13-;;/m0../s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C20H20N8Na2O5

                    

                    
                    

                        
HBD / HBA

                        
3 / 12

                    

                    
                    

                        
Liaisons Rotatives

                        
7

                    

                    
                    
                    

                        
Atomes Lourds

                        
35

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Foire aux questions

                

                    
                    

                        
                        

                            
A sodium salt form of methotrexate, used both as a chemotherapy agent for cancers and at low doses for autoimmune diseases such as rheumatoid arthritis and psoriasis.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Dihydrofolate reductase inhibitor.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Methotrexate Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3244648.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 11329481.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Avertissement médical

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.