Monomethyl Fumarate

CHEMBL589586 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

130.1 g/mol

LogP

0.4

Phase

4

This metabolite of dimethyl fumarate activates the Nrf2 pathway to reduce oxidative stress and inflammation, and modulates immune cell populations involved in autoimmune attacks on the nervous system in multiple sclerosis. It represents the active compound responsible for the therapeutic effects of fumarate-based treatments for MS and psoriasis.

Masse moléculaire

130,1000 g/mol

LogP

0,40

TPSA

63,60 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Psoriasis Multiple Sclerosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

COC(=O)/C=C/C(=O)O

InChI

InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+

Molecular Formula

C5H6O4

HBD / HBA

1 / 4

Liaisons Rotatives

3

Atomes Lourds

9

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

This metabolite of dimethyl fumarate activates the Nrf2 pathway to reduce oxidative stress and inflammation, and modulates immune cell populations involved in autoimmune attacks on the nervous system in multiple sclerosis. It represents the active compound responsible for the therapeutic effects of fumarate-based treatments for MS and psoriasis.

Yes, Monomethyl Fumarate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL589586. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5369209. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C5H6O4
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.