Nabumetone
This non-steroidal anti-inflammatory drug (NSAID) is used to relieve pain, swelling, and stiffness caused by arthritis. It works by blocking enzymes that produce inflammatory chemicals in the body, and it is taken once or twice daily with food to reduce stomach upset.
Masse moléculaire
228,2900 g/mol
LogP
3,10
TPSA
26,30 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Structure 2D
Cite this structure
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SMILES
COc1ccc2cc(CCC(C)=O)ccc2c1
InChI
InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3
Molecular Formula
C15H16O2
HBD / HBA
- / 2
Liaisons Rotatives
4
Atomes Lourds
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This non-steroidal anti-inflammatory drug (NSAID) is used to relieve pain, swelling, and stiffness caused by arthritis. It works by blocking enzymes that produce inflammatory chemicals in the body, and it is taken once or twice daily with food to reduce stomach upset.
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Yes, Nabumetone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1070. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4409. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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