Naloxone
This life-saving medication rapidly reverses an opioid overdose by blocking opioid receptors in the brain within minutes of administration. It is available as a nasal spray or injection and can be used by emergency responders or bystanders when someone is experiencing a potentially fatal opioid overdose.
Masse moléculaire
327,4000 g/mol
LogP
2,10
TPSA
70,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
Structure 2D
Cite this structure
Embed this structure
SMILES
C=CCN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5
InChI
InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
Molecular Formula
C19H21NO4
HBD / HBA
2 / 5
Liaisons Rotatives
2
Atomes Lourds
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This life-saving medication rapidly reverses an opioid overdose by blocking opioid receptors in the brain within minutes of administration. It is available as a nasal spray or injection and can be used by emergency responders or bystanders when someone is experiencing a potentially fatal opioid overdose.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Naloxone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL80. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5284596. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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