Nirogacestat

CHEMBL1770916 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

489.6 g/mol

LogP

4.8

Phase

4

A gamma-secretase inhibitor that blocks Notch signaling and reduces desmoid tumor growth, approved to treat adults with progressing desmoid tumors. It works by inhibiting an enzyme that cleaves Notch receptor proteins needed for tumor cell proliferation.

Masse moléculaire

489,6000 g/mol

LogP

4,80

TPSA

71,00 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Ovarian Cancer Breast Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CNCC(C)(C)C)cn1

InChI

InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1

Molecular Formula

C27H41F2N5O

HBD / HBA

3 / 6

Liaisons Rotatives

11

Atomes Lourds

35

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A gamma-secretase inhibitor that blocks Notch signaling and reduces desmoid tumor growth, approved to treat adults with progressing desmoid tumors. It works by inhibiting an enzyme that cleaves Notch receptor proteins needed for tumor cell proliferation.

Yes, Nirogacestat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1770916. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 46224413. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C27H41F2N5O
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.