Pentagastrin
A synthetic pentapeptide analogue of gastrin used diagnostically to stimulate gastric acid secretion and test the function of parietal cells, helping diagnose conditions such as pernicious anemia and Zollinger-Ellison syndrome. It is also used to stimulate calcitonin secretion as a provocative test for medullary thyroid carcinoma.
Masse moléculaire
767,9000 g/mol
LogP
1,50
TPSA
276,00 Ų
Règle des 5 de Lipinski
Non conforme
Aires thérapeutiques
Mécanisme d'action
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Structure 2D
Cite this structure
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SMILES
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
InChI
InChI=1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)/t26-,27-,28-,29-/m0/s1
Molecular Formula
C37H49N7O9S
HBD / HBA
8 / 10
Liaisons Rotatives
22
Atomes Lourds
54
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A synthetic pentapeptide analogue of gastrin used diagnostically to stimulate gastric acid secretion and test the function of parietal cells, helping diagnose conditions such as pernicious anemia and Zollinger-Ellison syndrome. It is also used to stimulate calcitonin secretion as a provocative test for medullary thyroid carcinoma.
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Yes, Pentagastrin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1328. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9853654. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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