Pexidartinib

CHEMBL3813873 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

417.8 g/mol

LogP

4.5

Phase

4

A kinase inhibitor used to treat tenosynovial giant cell tumor, a rare and often debilitating condition causing benign but destructive tumors in the joint lining. It works by blocking a signaling pathway that drives the abnormal growth of these tumor cells.

Masse moléculaire

417,8000 g/mol

LogP

4,50

TPSA

66,50 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Rheumatoid Arthritis Melanoma Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1

InChI

InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)

Molecular Formula

C20H15ClF3N5

HBD / HBA

2 / 7

Liaisons Rotatives

5

Atomes Lourds

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A kinase inhibitor used to treat tenosynovial giant cell tumor, a rare and often debilitating condition causing benign but destructive tumors in the joint lining. It works by blocking a signaling pathway that drives the abnormal growth of these tumor cells.

Yes, Pexidartinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3813873. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 25151352. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C20H15ClF3N5
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.