Phentolamine

CHEMBL597 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

281.4 g/mol

LogP

2.6

Phase

4

Used to treat and prevent high blood pressure episodes associated with pheochromocytoma, a tumor of the adrenal gland, by blocking receptors that cause blood vessel constriction. It may also be used to treat certain cases of hypertensive emergencies.

Masse moléculaire

281,3500 g/mol

LogP

2,60

TPSA

47,90 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Glaucoma Chronic Obstructive Pulmonary Disease Stroke Obesity Hypertension Heart Failure Prostate Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1

InChI

InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)

Molecular Formula

C17H19N3O

HBD / HBA

2 / 3

Liaisons Rotatives

4

Atomes Lourds

21

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

Used to treat and prevent high blood pressure episodes associated with pheochromocytoma, a tumor of the adrenal gland, by blocking receptors that cause blood vessel constriction. It may also be used to treat certain cases of hypertensive emergencies.

Yes, Phentolamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL597. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5775. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C17H19N3O
Synonymes: 3

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.