Rifabutin

CHEMBL444633 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

847.0 g/mol

LogP

5.6

Phase

4

An antibiotic used to prevent and treat Mycobacterium avium complex infections in people with HIV, and also used as part of combination regimens for tuberculosis. It works similarly to rifampin but has a different drug interaction profile, making it preferable in patients on certain HIV medications.

Masse moléculaire

847,0000 g/mol

LogP

5,60

TPSA

209,00 Å²

Règle des 5 de Lipinski

Non conforme

Aires thérapeutiques

Multiple Sclerosis HIV/AIDS Tuberculosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(c3C2=O)C2=NC3(CCN(CC(C)C)CC3)NC2=C(NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C4=O

InChI

InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14-/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1

Molecular Formula

C46H62N4O11

HBD / HBA

5 / 14

Liaisons Rotatives

5

Atomes Lourds

61

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

An antibiotic used to prevent and treat Mycobacterium avium complex infections in people with HIV, and also used as part of combination regimens for tuberculosis. It works similarly to rifampin but has a different drug interaction profile, making it preferable in patients on certain HIV medications.

Yes, Rifabutin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL444633. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 135415564. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C46H62N4O11
Synonymes: 2

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.