Sulfur
Sulfur is an elemental non-metal with keratolytic, antifungal, and antibacterial properties, used topically for treatment of acne, seborrheic dermatitis, rosacea, scabies, and psoriasis. Its mechanism involves formation of hydrogen sulfide and pentathionic acid by skin surface bacteria, which are directly toxic to Sarcoptes scabiei mites and bacteria, and keratolytic activity that reduces comedone formation. It is one of the oldest medicinal substances and remains in use in over-the-counter topical formulations.
Masse moléculaire
32,0700 g/mol
LogP
0,50
TPSA
1,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Promotes the shedding of the outer layer of skin (stratum corneum) by disrupting intercellular adhesion between keratinocytes. This softens and removes thickened, scaly, or hyperkeratotic skin.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Promotes the shedding of the outer layer of skin (stratum corneum) by disrupting intercellular adhesion between keratinocytes. This softens and removes thickened, scaly, or hyperkeratotic skin.
Structure 2D
Cite this structure
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SMILES
S1SSSSSSS1
InChI
InChI=1S/S8/c1-2-4-6-8-7-5-3-1
Molecular Formula
S
HBD / HBA
- / 1
Liaisons Rotatives
0
Atomes Lourds
1
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Sulfur is an elemental non-metal with keratolytic, antifungal, and antibacterial properties, used topically for treatment of acne, seborrheic dermatitis, rosacea, scabies, and psoriasis. Its mechanism involves formation of hydrogen sulfide and pentathionic acid by skin surface bacteria, which are directly toxic to Sarcoptes scabiei mites and bacteria, and keratolytic activity that reduces comedone formation. It is one of the oldest medicinal substances and remains in use in over-the-counter topical formulations.
Promotes the shedding of the outer layer of skin (stratum corneum) by disrupting intercellular adhesion between keratinocytes. This softens and removes thickened, scaly, or hyperkeratotic skin.
Yes, Sulfur is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1235452. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5362487. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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