Tavaborole
Tavaborole is a topical oxaborole antifungal agent that inhibits fungal cytoplasmic leucyl-transfer RNA synthetase (LeuRS), a novel mechanism distinct from azoles and allylamines. It is approved for the treatment of onychomycosis (fungal nail infection) caused by Trichophyton rubrum and T. mentagrophytes. Its low molecular weight allows effective nail plate penetration, overcoming a major limitation of topical antifungal therapy.
Masse moléculaire
151,9300 g/mol
TPSA
29,50 Ų
Mécanisme d'action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Structure 2D
Cite this structure
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SMILES
OB1OCc2cc(F)ccc21
InChI
InChI=1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
Molecular Formula
C7H6BFO2
HBD / HBA
1 / 3
Liaisons Rotatives
0
Atomes Lourds
11
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Tavaborole is a topical oxaborole antifungal agent that inhibits fungal cytoplasmic leucyl-transfer RNA synthetase (LeuRS), a novel mechanism distinct from azoles and allylamines. It is approved for the treatment of onychomycosis (fungal nail infection) caused by Trichophyton rubrum and T. mentagrophytes. Its low molecular weight allows effective nail plate penetration, overcoming a major limitation of topical antifungal therapy.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Tavaborole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL443052. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11499245. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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