Unoprostone Isopropyl
Unoprostone isopropyl is a docosanoid analog (derived from a urinary metabolite of prostaglandin) that reduces intraocular pressure by increasing aqueous humor outflow through uveoscleral and trabecular meshwork pathways. It is used in the management of open-angle glaucoma and ocular hypertension as a topical ophthalmic agent. Its prostaglandin-related mechanism complements other classes of glaucoma medications.
Masse moléculaire
424,6000 g/mol
LogP
4,90
TPSA
83,80 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Structure 2D
Cite this structure
Embed this structure
SMILES
CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O
InChI
InChI=1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8-/t21-,22-,23+,24-/m1/s1
Molecular Formula
C25H44O5
HBD / HBA
2 / 5
Liaisons Rotatives
17
Atomes Lourds
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Unoprostone isopropyl is a docosanoid analog (derived from a urinary metabolite of prostaglandin) that reduces intraocular pressure by increasing aqueous humor outflow through uveoscleral and trabecular meshwork pathways. It is used in the management of open-angle glaucoma and ocular hypertension as a topical ophthalmic agent. Its prostaglandin-related mechanism complements other classes of glaucoma medications.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Unoprostone Isopropyl is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200661. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5282175. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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