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CDK4/CDK6 (Cyclin-Dependent Kinase 4/6)

CDK4/CDK6

Cell cycle kinases driving G1-to-S phase transition via Rb phosphorylation.

Fonction

CDK4/6 inhibitors (palbociclib, ribociclib) restore cell cycle arrest in HR+/HER2- breast cancer.

Related Targets

BRAF (BRAF Kinase) BRAF BCR-ABL1 (BCR-ABL Fusion Protein) BCR-ABL1 EGFR (Epidermal Growth Factor Receptor) EGFR KDR (Vascular Endothelial Growth Factor Receptor 2) KDR MTOR (Mechanistic Target of Rapamycin) MTOR ALK (Anaplastic Lymphoma Kinase) ALK