Amlodipine vs Captopril

## Amlodipine vs Captopril: Overview

This comparison examines the pharmacological differences between **Amlodipine** and **Captopril**.

## Mechanism of Action

**Amlodipine**: Dihydropyridine calcium channel blocker.

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

## Pharmacokinetics

**Half-life**: Amlodipine — 30-50 hours; Captopril — 1.9 hours.

## Chemical Properties

**Molecular Formula**: Amlodipine — C20H25ClN2O5; Captopril — C9H15NO3S.

**Molecular Weight**: Amlodipine — 408.8800 g/mol; Captopril — 217.2850 g/mol.

**Type**: Amlodipine — Small molecule; Captopril — Small molecule.