Canagliflozin vs Methotrexate

## Canagliflozin vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Canagliflozin** and **Methotrexate**.

## Mechanism of Action

**Canagliflozin**: Selective SGLT2 inhibitor reducing renal glucose reabsorption and lowering blood glucose.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Canagliflozin — 10.6 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Canagliflozin — C24H25FO5S; Methotrexate — C20H22N8O5.

**Molecular Weight**: Canagliflozin — 444.5170 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Canagliflozin — Small molecule; Methotrexate — Small molecule.