Captopril vs Nitroglycerin

## Captopril vs Nitroglycerin: Overview

This comparison examines the pharmacological differences between **Captopril** and **Nitroglycerin**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Nitroglycerin**: Nitric oxide donor causing venous and arterial vasodilation.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Nitroglycerin — 1-4 minutes.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Nitroglycerin — C3H5N3O9.

**Molecular Weight**: Captopril — 217.2850 g/mol; Nitroglycerin — 227.0870 g/mol.

**Type**: Captopril — Small molecule; Nitroglycerin — Small molecule.